Dendrobium officinale is found on semi-wet rocks in mountains up to 1600 meters above sea level. Mainly distributed in Anhui, Zhejiang, Fujian and other places in China. Its stem into medicine, is a tonic medicine in Yin medicine: Yiwei Shengjin, Yiyin Qingreqi. TRUFEREAU DDB was fermented by Dendrobium officinale and Lactobacillus. After fermentation, the molecular weight was smaller and it was easier to be absorbed by the skin. Dendrobium officinale has anti-aging effect, can delay the skin aging, restore the skin youthful luster.